Zestoretic is a medication in tablet form that combines two active ingredients, Hydrochlorothiazide and Lisinopril, to effectively manage high blood pressure (hypertension). By lowering blood pressure, Zestoretic helps to reduce the risk of cardiovascular events such as heart attacks and strokes. In different regions, this product may be available under alternative brand names including Cipril-H, Lipril-H, Listril Plus, and Lispro-H.